NAT2PRED: a web-server for inferring the acetylator phenotype of the human
N-acetyltransferase-2 (NAT2) from NAT2 genotype

[HELP]

N-acetyltransferase-2 (NAT2) is an enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Based on the level of NAT2 enzymatic activity, individuals in human populations are divided into three acetylator phenotypes: slow, rapid, and intermediate. This web-server implements a support vector machine (SVM) predictor of the human NAT2 acetylator phenotype that uses a combination of SNPs found in the NAT2 gene positions 282, 341, 481, 590, 803, and 857. The predictor assigns one of the three NAT2 phenotypes based on the genotypes observed for these six SNPs. It achieves 99.9% accuracy and class-specific sensitivities and specificities in the range between 99.6% and 100%.

Please select a NAT2 genotype using radio buttons below and click 'submit'.
Refer to [help page] for more information.

Click here for batch submission of multiple genotypes (results will be returned by E-mail)

Citation:

I.B.Kuznetsov, M.McDuffie, R.Moslehi, 2009, A web-server for inferring the human N-acetyltransferase-2 (NAT2)
enzymatic phenotype from NAT2 genotype. Bioinformatics, 25(9):1185-1186

Please address your questions and comments to Igor Kuznetsov